本公司经销CD19，CD19抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD19CD19抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0079R
英文名称：Anti-CD19
中文名称：CD19抗体
其他名称：Antibody deficiency due to defect in CD19, included; AW495831; B lymphocyte antigen CD19; B lymphocyte surface antigen B4; B4; CD 19; CD19 antigen; CD19 molecule; Cd19 protein; Differentiation Antigen CD19; Leu 12; Leu12; Lymphocyte Surface Antigen; MGC109570; MGC12802; T-cell surface antigen Leu-12.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 59kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, hrs, Gpig
产品介绍：CD19 is a transmembrane glycoprotein that is delectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras ａnd phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate ａnd differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Function : Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.Subunit : Forms a complex with CD21, CD81 ａnd CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 ａnd SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.Subcellular Location : Membrane; Single-pass type I membrane protein.Post-translational modifications : Phosphorylated on serine ａnd threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.DISEASE : Defects in CD19 are the cause of immunodeficiency common variable type 3 （CVID3） [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections ａnd an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation ａnd impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.Similarity : Contains 2 Ig-like C2-type （immunoglobulin-like） domains.CD19是一种质膜蛋白质，参与信号传导作用。表达与前B细胞和成熟的B细胞膜表面，与B细胞的活化调节和发育调节相关，在T细胞和正常粒细胞上无表达。此抗体可以特异性识别CD19，主要用于标记正常B细胞及肿瘤性B细胞。产品图片Tissue/cell: rat transplant lymphoma; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-CD19 Polyclonal Antibody, Unconjugated（bs-0079R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingTissue/cell: human rectal carcinoma; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-CD19 Polyclonal Antibody, Unconjugated（bs-0079R） 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, PE conjugated（bs-0295G-Cy5）used at 1:200 dilution for 40 minutes at 37°C.