本公司经销CD2AP，白细胞分化抗原CD2AP抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD2AP白细胞分化抗原CD2AP抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0512R
英文名称：Anti-CD2AP
中文名称：白细胞分化抗原CD2AP抗体
其他名称：CD2-associated protein; Adapter protein CMS; AL024079; Cas ligand with multiple SH3 domains; C78928; Cd2ap; CMS; Mesenchyme to epithelium transition protein with SH3 domains 1; METS 1; Mets1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 70kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：CD2-associated protein may be a cell membrane molecule breaks the connection with the cytoskeleton protein in the cell proliferation that is of course an important role to play. At present, the main use for kidney function studies, CD2-associated protein not only involved in the activation of T cells ａnd kidney function plays a vital role in the abnormal expression may be caused by human factors of kidney disease.Subunit : Self-associates. Homodimer （Potential）. Interacts （via SH3 2 domain） with CBL （via phosphorylated C-terminus）. Interacts with BCAR1/p130Cas （via SH3 domain）. Interacts with F-actin, PKD2, NPHS1 ａnd NPHS2. Interacts with WTIP （By similarity）. Interacts with FAM125A ａnd ARHGAP17. Interacts with ANLN, CD2 ａnd CBLB. Interacts with PDCD6IP ａnd TSG101. Interacts with DDN; interaction is direct （By similarity）.Subcellular Location : Cytoplasm, cytoskeleton （By similarity）. Cell projection, ruffle （By similarity）. Note=Colocalizes with F-actin ａnd BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes （By similarity）. During late anaphase ａnd telophase, concentrates in the vicinity of the midzone microtubules ａnd in the midbody in late telophase.Tissue Specificity : Widely expressed in fetal ａnd adult tissues.Similarity : Contains 3 SH3 domains.CD2AP可能作为细胞裂孔隔膜分子与细胞骨架的连接蛋白，在细胞分化即增殖的过程中发挥重要作用。 目前主用用于肾脏功能方面的研究，D2AP不仅参与T细胞的活化，而且对肾脏功能起着至关重要的作用，其异常表达可能是引起人类肾脏疾病的诱因。产品图片Tissue/cell: rat lung tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-CD2AP Polyclonal Antibody, Unconjugated（bs-0512R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingTissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-CD2AP Polyclonal Antibody, Unconjugated（bs-0512R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining