本公司经销CEA/CD66e/CEACAM5，癌胚抗原抗体，克隆类型为polyclonal，宿主来源是Rabbit，CEA/CD66e/CEACAM5癌胚抗原抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0060R
英文名称：Anti-CEA/CD66e/CEACAM5
中文名称：癌胚抗原抗体
其他名称：Carcino Embryonic Antigen CEA; CEACAM 5; CEACAM-5; Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 150-200kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：CEA-related cell adhesion molecules （CEACAM） belong to the carcinoembryonic antigen （CEA） family. It consists of seven CEACAM （CEACAM 1, CEACAM 3-CEACAM 8） ａnd 11 pregnancy-specific glyco-protein （PSG 1-PSG 11） members. The CEA family proteins belong to the immunoglobulin （Ig） superfamily ａnd are composed of one Ig variable-like （IgV） ａnd a varying number （0-6） of Ig constant-like （IgC） domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol （GPI） anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte ａnd dendritic cell activation, receptors of Neisseria species ａnd other bacteria.Function : Cell surface glycoprotein that plays a role in cell adhesion ａnd in intracellular signaling. Receptor for E.coli Dr adhesins.Subunit : Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchorTissue Specificity : Found in adenocarcinomas of endodermally derived digestive system epithelium ａnd fetal colon.Similarity : Belongs to the immunoglobulin superfamily. CEA family. Contains 7 Ig-like （immunoglobulin-like） domains.CEA是一种胚胎性抗原，主要存在于胎儿消化道上皮组织，胰腺和肝癌中。CEA广泛存在各种上皮性肿瘤，尤其是胃肠道恶性肿瘤，CEA分布阳性类型与肿瘤的恶性度有关。CEA与EMA一样可作为上皮性恶性肿瘤的重要标记。