产品展示
Anti-CXC-R2CXCR2/CD182
点击次数：251发布时间：2012/12/26 8:48:53
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-4836R
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详细内容
货号：BY-4836R
英文名称：Anti-CXC-R2
中文名称：CXCR2/CD182
其他名称：CXC-chemokine receptor 2; CD 182; CD182; CD182 antigen; CDw128b; Chemokine （CXC） receptor 2; CMKAR2; CXCR 2; CXC R2; CXC-R2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 （IL8）. It binds to IL8 with high affinity, ａnd transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine （C-X-C motif） ligand 1 （CXCL1/MGSA）, a protein with melanoma growth stimulating activity, ａnd has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.Subcellular Location : Cell membrane.Similarity : Belongs to the G-protein coupled receptor 1 family.
