本公司经销Caldesmon，钙介质素抗体，克隆类型为polyclonal，宿主来源是Rabbit，Caldesmon钙介质素抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1589R
英文名称：Anti-Caldesmon
中文名称：钙介质素抗体
其他名称：CAD; CALD 1; CALD1; Caldesmon 1; Caldesmon 1 Isoform 1; Caldesmon 1 Isoform 2; Caldesmon 1 Isoform 3; Caldesmon 1 Isoform 4; Caldesmon 1 Isoform 5; Caldesmon1; CDM; H CAD; HCAD; L CAD; LCAD; MGC21352; NAG22.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 120-150kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Caldesmon is a smooth muscle ａnd nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, ａnd calmodulin. Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, ａnd actin-binding region at the C-terminus ａnd a myosin-binding domain at the N-terminus. Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin ａnd is promoted by tropomyosin. Caldesmon occurs in both a high molecular weight （120-150 kDa） ａnd a low molecular weight （61-70 kDa） form, depending on the tissue in which it is located.Function : Actin- ａnd myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle ａnd nonmuscle cells （could act as a bridge between myosin ａnd actin filaments）. Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin ａnd is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin ａnd with calmodulin. Also play an essential role during cellular mitosis ａnd receptor capping.Subcellular Location : Cytoplasm > cytoskeleton. Cytoplasm > myofibril. On thin filaments in smooth muscle ａnd on stress fibers in fibroblasts （nonmuscle）.Tissue Specificity : High-molecular-weight caldesmon （isoform 1） is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon （isoforms 2, 3, 4 ａnd 5） are widely distributed in non-muscle tissues ａnd cells. Not expressed in skeletal muscle or heart.Similarity : Belongs to the caldesmon family.Caldesmon是一种平滑肌肌动蛋白和钙调蛋白的结合蛋白，被认为是一种平滑肌细胞的标志物,存在于平滑肌或非平滑肌细胞中的一种细胞骨架蛋白。它可以与肌动蛋白、肌球蛋白、原肌球蛋白和钙调蛋白相互作用，是平滑肌细胞的一个标志物，可用于判断子宫肿瘤来源。在结肠直肠肿瘤中是区分纤维细胞和肌纤维细胞的一个标志物。