本公司经销Phospho-cdc25A （Ser76），磷酸化细胞分裂周期蛋白25抗体，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-cdc25A （Ser76）磷酸化细胞分裂周期蛋白25抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3094R
英文名称：Anti-Phospho-cdc25A （Ser76）
中文名称：磷酸化细胞分裂周期蛋白25抗体
其他名称：cdc25A（Phospho-Ser76）; Cdc 25a; CDC25A2; Cell division cycle 25 homolog A （S. pombe）; Cell division cycle 25A; Cell division cycle 25A isoform a; Cell division cycle 25A isoform bv D9Ertd393ev Dual specificity phosphatase CDC25A; EC 3.1.3.48; M phase inducer phosphatase 1; MGC115549;
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 59kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Cyclin dependent kinases are positively regulated by association with cyclins ａnd negatively regulated by binding to inhibitory subunits. The activity of cyclin dependent kinases is also regulated by the phosphorylation status, which is controlled by the antagonistic action of Wee1 kinase ａnd CDC25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, ａnd CDC25C. These three genes function at different phases of the cell cycle. Whereas CDC25A ａnd CDC25B are expressed throughout the cell cycle, with peak expression in G1 for CDC25A ａnd in both G1 S phase ａnd G2 for CDC25B, CDC25C is predominantly expressed in G2. Function : Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 ａnd stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.Post-translational modifications : Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 ａnd Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, ａnd Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 ａnd Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 ａnd Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 ａnd Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination ａnd degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination ａnd degradation.Similarity : Belongs to the MPI phosphatase family.Contains 1 rhodanese domain.CDC25家族的组成哺乳动物中CDC25家族一共包括3种同源异构体（CDC25A、CDC25B、CDC25C），约有50%的序列同源，是一组在细胞周期调控中发挥巨大作用的苏/酪氨酸双功能酶 。不同的CDC25家族蛋白在细胞周期中的作用时相亦有差异，CDC25A和CDC25C分别在S期和M期发挥主要作用。