本公司经销caspase-8 subunit p18，半胱氨酸蛋白酶8抗体，克隆类型为polyclonal，宿主来源是Rabbit，caspase-8 subunit p18半胱氨酸蛋白酶8抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6463R
英文名称：Anti-caspase-8 subunit p18
中文名称：半胱氨酸蛋白酶8抗体
其他名称：Caspase-8 subunit p18; ALPS2B; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein; Apoptosis related cysteine peptidase; Apoptotic cysteine protease; Apoptotic protease Mch 5; Apoptotic protease Mch-5; Apoptotic protease Mch5; CAP 4; CAP4; CASP 8; CASP-8; CASP8; CASP8_HUMAN; Caspase 8; Caspase 8 apoptosis related cysteine peptidase; Caspase-8 subunit p18; Caspase8; CED 3; FADD homologous ICE/CED 3 like protease; FADD Homologous ICE/CED3 Like Protease; FADD Like ICE; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; FLJ17672; ICE like apoptotic protease 5; ICE-like apoptotic protease 5; MACH alpha 1/2/3 protein; MACH; MACH beta 1/2/3/4 protein; MCH 5; MCH5; MGC78473; MORT1 associated CED 3 homolog; MORT1 associated CED3 homolog; MORT1-associated CED-3 homolog; OTTHUMP00000163717; OTTHUMP00000163720; OTTHUMP00000163724; OTTHUMP00000163725; OTTHUMP00000165062; OTTHUMP00000165063; OTTHUMP00000165064; OTTHUMP00000206552; OTTHUMP00000206582
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 18/48kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Initiator caspases, which include caspase-8, activate effector caspases by cleaving inactive forms of effector caspases. In the activation cascade responsible for apoptosis induced by TNFRSF1A ａnd mediated by TNFRSF6/FAS, caspase-8 is the most upstream protease. Caspase-8 binds to adaptor molecule FADD, forming an aggregate referred to as death-inducing signaling complex （DISC）, which activates caspase-8. The actived protein is released from the complex ａnd further activates downstream apoptotic proteases. Caspase-8, which is a heterodimer consisting of two subunits （p18 ａnd p10）, is widely expressed, but is detected at highest levels in peripheral blood leukocytes （PBLs）, thymus, liver ａnd spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D （caspase-8 deficiency disorder）, which is characterized by splenomegaly ａnd CD95-induced apoptosis of PBLs, ａnd may lead to immunodeficiency due to defects in T lymphocyte, NK cell ａnd B lymphocyte activation.Subunit : Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa （p18） ａnd a 10 kDa （p10） subunit. Interacts with FADD, CFLAR ａnd PEA15. Isoform 9 interacts at the endoplasmic reticulum with a complex containing BCAP31, BAP29, BCL2 and/or BCL2L1. Interacts with TNFAIP8L2.Subcellular Location : Cytoplasm.Tissue Specificity : Isoform 1, isoform 5 ａnd isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus ａnd liver. Barely detectable in brain, testis ａnd skeletal muscle.Similarity : Belongs to the peptidase C14A family.Contains 2 DED （death effector） domains.