本公司经销caspase-9 p10，半胱胺酸蛋白酶蛋白9-p10抗体，克隆类型为polyclonal，宿主来源是Rabbit，caspase-9 p10半胱胺酸蛋白酶蛋白9-p10抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-8502R
英文名称：Anti-caspase-9 p10
中文名称：半胱胺酸蛋白酶蛋白9-p10抗体
其他名称：APAF 3; APAF3; Apoptosis related cysteine peptidase; Apoptotic protease activating factor 3; Apoptotic protease MCH 6; Apoptotic protease MCH6 antibodyCASP 9; CASP9; Caspase 9; Caspase 9 apoptosis related cysteine protease; Caspase 9 precursor; Caspase 9 subunit p10; Caspase 9c; Caspase9; Caspase9 subunit p10; ICE LAP6; ICE like apoptotic protease 6; MCH 6; MCH6; OTTHUMP00000044594.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 10/50kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, hrs, dog, chk, Rb
产品介绍：A unique family of cysteine proteases has been described that differs in sequence, structure ａnd substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 （also designated Mch3, ICE-LAP3 or CMH-1）, caspase-9 ａnd caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery ａnd act to destroy specific target proteins which are critical to cellular longevity. Poly（ADP-ribose） polymerase plays an integral role in surveying for DNA mutations ａnd double strand breaks. Caspase-3, caspase-7 ａnd caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope ａnd cellular morphology. Caspase-10 has been shown to activate caspase-3 ａnd caspase-7 in response to apoptotic stimuli.Function : Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves ａnd activates caspase-3. Proteolytically cleaves poly（ADP-ribose） polymerase （PARP）.Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.Subunit : Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa （p35） ａnd a 10 kDa （p10） subunit. Caspase-9 ａnd APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C ａnd ATP. Interacts （inactive form） with EFHD2. Interacts with HAX1. Interacts with BIRC2/c-IAP1, XIAP/BIRC4, BIRC5/survivin, BIRC6/bruce ａnd BIRC7/livin.Tissue Specificity : Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, ａnd pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.Post-translational modifications : Cleavages at Asp-315 by granzyme B ａnd at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 ａnd -10 can also be involved in these processing events.Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing ａnd subsequent caspase-3 activation.Similarity : Belongs to the peptidase C14A family.Contains 1 CARD domain.