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Anti-Phospho-Cyclin B1(Ser133)磷酸化周期素B1抗体
点击次数：293发布时间：2012/12/26 8:58:15
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-3123R
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货号：BY-3123R
英文名称：Anti-Phospho-Cyclin B1（Ser133）
中文名称：磷酸化周期素B1抗体
其他名称：CCNB 1; CCNB; CCNB1; G2 mitotic specific cyclin B1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 48kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig
产品介绍：In mammals, cyclin B associates with inactive p34 cdc2 which facilitates phosphorylation of p34 cdc2 at amino acids 14 Thr ａnd 15 Tyr. This maintains the inactive state until the end of G2 phase. The inactive cyclin B p34 cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates amino acids 14Thr ａnd 15Tyr of p34 cdc2, rendering the complex active at the G2 / M boundary. This mitotic kinase complex remains active until the metaphase / anaphase transition when cyclin B is degraded. This degradation process is ubiquitin dependent ａnd is necessary for the cell to exit mitosis. Therefore, cyclin B p34 cdc2 plays a critical role in G2 to M transition. Two alternative transcripts have been found, a constitutively expressed transcript, ａnd a cell cycle-regulated transcript that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.Subunit : Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor （MPF）. The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 ａnd CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization.Subcellular Location : Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.Similarity : Belongs to the cyclin family. Cyclin AB subfamily.主要出现在G2期。Cyclin B是细胞周期调节必不可少的条件。 细胞周期素B1是细胞周期调节因子，它的异常表达将导致细胞周期发生紊乱，致使肿瘤形成.
