本公司经销E-cadherin/CD324，上皮钙粘附分子抗体，克隆类型为polyclonal，宿主来源是Rabbit，E-cadherin/CD324上皮钙粘附分子抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1016R
英文名称：Anti-E-cadherin/CD324
中文名称：上皮钙粘附分子抗体
其他名称：anion exchanger protein 3; Arc 1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 234; CD324; CD324 antigen;CDH1; CDHE;ECAD;Epithelial cadherin; epithelial calcium dependant adhesion protein;LCAM; Liver cell adhesion molecule; UVO; Uvomorulin.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 80kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, pig, hrs, chk
产品介绍：Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure ａnd morphogenesis. Members of this family of adhesion proteins include rat cadherin K （and its human homolog, cadherin-6）, R-cadherin, B-cadherin, E/P cadherin ａnd cadherin-5. The classical cadherins, E-, N- ａnd P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains ａnd carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as ∫-catenin, to regulate cadherin function.Function : Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility ａnd proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 ａnd C83 production.Subunit : Homodimer.Subcellular Location : Cell junction. Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Non-neural epithelial tissues.DISEASE : Defects in CDH1 are the cause of hereditary diffuse gastric cancer （HDGC） . An autosomal dominant cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, ａnd can extend through the stomach wall to nearby lymph nodes ａnd organs. It also can metastasize to other parts of the body. Note=Heterozygous germline mutations CDH1 are responsible for familial cases of diffuse gastric cancer. Somatic mutations in the has also been found in patients with sporadic diffuse gastric cancer ａnd lobular breast cancer.Similarity : Contains 5 cadherin domains.