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Anti-CFTR囊性纤维化跨膜转运调节因子抗体
点击次数：354发布时间：2012/12/26 9:01:24
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-1277R
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货号：BY-1277R
英文名称：Anti-CFTR
中文名称：囊性纤维化跨膜转运调节因子抗体
其他名称：ABC 35; ABC35; ABCC 7; ABCC7; ATP binding cassette sub family C member 7; ATP Binding Cassette Superfamily C Member 7; ATP binding cassette transporter sub family C member 7; cAMP dependent chloride channel; CF; CFTR/MRP; Channel conductance controlling ATPase; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7; Cystic Fibrosis Transmembrane Regulator; dJ760C5.1; MRP 7; MRP7; TNR CFTR.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 162kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, pig, Rb, hrs, shp, chk, cow, dog
产品介绍：CFTR （cystic fibrosis transmembrane conductance regulator） the membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette （ABC） transporters. ABC proteins transport various molecules across extra- ａnd intra-cellular membranes. ABC genes are divided into seven distinct subfamilies （ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White）. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This gene encodes the cystic fibrosis transmembrane regulator ａnd a chloride channel that controls the regulation of other transport pathways. Mutations in this gene have been associated with autosomal recessive disorders such as cystic fibrosis ａnd congenital bilateral aplasia of the vas deferens. Alternative splicing of exons 4, 5, and11 have been observed, but full-length transcripts have not yet been fully described. Belongs to the ABC transporter family.CFTR是一种独特的氯离子通道，尽管称为氯离子通道，但在结构上却明显地不同于其他氯离子通道，属于一种ATP结合盒转运体（ATP-binding cassettetransporter, ABC）家族。CFTR主要为氯离子跨上皮运动提供了选择性通道，对于跨上皮的盐类运输、液体流动和离子浓度调节等都具有重要的决定作用。 CFTR分布广泛，许多器官，如肺、肝、胰腺、肠、生殖腺等的细胞膜中都有表达，尽管称为氯离子通道，但还涉及到其他一价阴离子的运输，由于生理条件下氯离子*为重要，故称为氯离子通道，近年来，它一直是离子通道研究中的一个热点。
