本公司经销CD40L/CD154，CD40L抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD40L/CD154CD40L抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1286R
英文名称：Anti-CD40L/CD154
中文名称：CD40L抗体
其他名称：TNFSF5; CD 154; CD 40L; CD154; CD154 antigen; CD40 homologue; CD40 ligand; CD40LG; gp39; hCD40L; HIGM1; Hyper IgM syndrome; IGM; IMD3; Ly62; T B cell activating molecule; T cell antigen GP39; TBAM; TNF related activation protein; TNF superfamily member 5; Tnfsf5; TRAP; Tumor necrosis factor （ligand） superfamily member 5.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 29kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：CD40 ligand （CD40L） is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes, but also exists as a soluble form extracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, which is expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells, vascular endothelial cells, ａnd epithelial cells. CD40L plays an important role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with B cells expressing CD40, ａnd activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linked immunodeficiency disease that is characterized by elevated level of serum IgM ａnd decreased level of other isotypes.Function : Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, ａnd an matrix metalloproteinases （MMP） inhibitor-sensitive pathway.Subcellular Location : Secreted ａnd Cell membrane.Tissue Specificity : Specifically expressed on activated CD4+ T-lymphocytes.DISEASE : Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 （HIGM1） [MIM:308230]; also known as X-linked hyper IgM syndrome （XHIM）. HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM ａnd decreased amounts of all other isotypes. Affected males present at an early age （usually within the first year of life） recurrent bacterial ａnd opportunistic infections, including Pneumocystis carinii pneumonia ａnd intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.Similarity : Belongs to the tumor necrosis factor family.CD40L也是T细胞活化的重要辅助刺激通路,不仅在调节T细胞免疫反应中起关键作用,而且也在B细胞的活化、增殖、分化、抗体的分泌起重要作用。主要表达在B细胞，有抗凋亡和促生长、分化的作用。产品图片Antigen: bs-1286P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.