本公司经销CTLA-4/CD152，细胞毒性T细胞抗原-4抗体，克隆类型为polyclonal，宿主来源是Rabbit，CTLA-4/CD152细胞毒性T细胞抗原-4抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1179R
英文名称：Anti-CTLA-4/CD152
中文名称：细胞毒性T细胞抗原-4抗体
其他名称：CD 152; CD152; CD152 antigen; CD28; Celiac disease 3; CELIAC3; CTLA 4; CTLA 4; CTLA4; Cytotoxic T cell associated 4; Cytotoxic T lymphocyte associated 4; Cytotoxic T lymphocyte associated antigen 4; Cytotoxic T lymphocyte associated protein 4; Cytotoxic T lymphocyte associated serine esterase 4; Cytotoxic T lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; Cytotoxic T-lymphocyte-associated protein 4; GSE; IDDM12.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 21kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb
产品介绍：This gene is a member of the immunoglobulin superfamily ａnd encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, ａnd a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, ａnd other autoimmune diseases.Function : Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 ａnd CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.Subunit : Homodimer; disulfide-linked. Binds to CD80/B7-1 ａnd CD86/B7.2.Subcellular Location : Cell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface ａnd rapid internalisation.Tissue Specificity : Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.Post-translational modifications : N-glycosylation is important for dimerization.Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, ａnd leads to retention of CTLA4 on the cell surface.DISEASE : Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus （SLE） [MIM:152700]. SLE is a chronic, inflammatory ａnd often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys ａnd serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system.Note=Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland ａnd hyperthyroidism.Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 （IDDM12） [MIM:601388]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia ａnd polyuria which result from hyperglycemia-induced osmotic diuresis ａnd secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, ａnd blood vessels.Similarity : Contains 1 Ig-like V-type （immunoglobulin-like） domain.CTLA4（细胞毒性T细胞抗原4），CTLA-4是位于T淋巴细胞膜上的跨膜免疫应答受体分子，CTLA-4对T淋巴细胞的活化具有负调控作用，有学者认为；CTLA-4可以参与免疫系统的功能，对肿瘤起到有效的抑制作用。