本公司经销Connexin 43，间隙连接蛋白43抗体，克隆类型为polyclonal，宿主来源是Rabbit，Connexin 43间隙连接蛋白43抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0651R
英文名称：Anti-Connexin 43
中文名称：间隙连接蛋白43抗体
其他名称：Connexin 43; Connexin43v; Cx 43v; CX43; CX 43; CX-43; DFNB38; Gap junction 43 kDa heart protein;Connexin-43; Gap junction alpha 1 protein; Gap junction protein alpha 1 43kDa （connexin 43）; Gap junction protein alpha 1 43kDa; Gap junction protein alpha like; GJA 1; GJA1; GJA-1; GJAL; HGNC:4282; HGNC:8112; Oculodentodigital dysplasia; ODD; ODOD; SDTY3; Syndactyly type III.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, cow, dog, chp, chk
产品介绍：Vascular smooth muscle connexin-43 is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart ａnd in embryonic development. Mutations in this gene have been associated with oculodentodigital dysplasia ａnd heart malformations.Function : Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical ａnd chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli ａnd causing them to contract.Subunit : A connexon is composed of a hexamer of connexins. Interacts （via C-terminus） with TJP1. Interacts （via C-terminus） with SRC （via SH3 domain）. Interacts with UBQLN4. Interacts with SGSM3. Interacts with KIAA1432/CIP150. Interacts with CNST ａnd CSNK1D.Subcellular Location : Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.Tissue Specificity : Expressed in the heart ａnd fetal cochlea.Post-translational modifications : Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques ａnd inhibition of gap junction activity. Phosphorylation at Ser-325, Ser-328 ａnd Ser-330 by CK1 modulates gap junction assembly.DISEASE : Defects in GJA1 are the cause of autosomal dominant oculodentodigital dysplasia （ODDD） [MIM:164200]; also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial （ocular, nasal, dental） ａnd limb dysmorphisms, spastic paraplegia, ａnd neurodegeneration. Craniofacial anomalies tipically include a thin nose with hypoplastic alae nasi, small anteverted nares, prominent columnella, ａnd microcephaly. Brittle nails ａnd hair abnormalities of hypotrichosis ａnd slow growth are present. Ocular defects include microphthalmia, microcornea, cataracts, glaucoma, ａnd optic atrophy. Syndactyly type 3 ａnd conductive deafness can occur in some cases. Cardiac abnormalities are observed in rare instances.Similarity : Belongs to the connexin family. Alpha-type （group II） subfamily.间隙连接蛋白-43（Gap junction alpha-1 protein; GJA-1; （Vascular smooth muscle connexin-43））是构成细胞间的通道，小分子成份可以借此在细胞间扩散。Connexin-43也是心肌缝隙连接的主要蛋白。 此外，星形细胞、成纤维细胞、平滑肌和肾等组织也有表达Connexin 43.产品图片Tissue/cell: rat heart tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Connexin 43 Polyclonal Antibody, Unconjugated（bs-0651R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingTissue/cell: rat heart tissue;4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Connexin 43 Polyclonal Antibody, Unconjugated（bs-0651R） 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, PE conjugated（bs-0295G-PE）used at 1:200 dilution for 40 minutes at 37°C.