本公司经销Cyclin D1/FSTL3，周期素D1抗体，克隆类型为polyclonal，宿主来源是Rabbit，Cyclin D1/FSTL3周期素D1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0623R
英文名称：Anti-Cyclin D1/FSTL3
中文名称：周期素D1抗体
其他名称：Cyclin D1; CyclinD1; Cyclin-D1; B cell ccl/lymphoma 1; B cell leukemia 1; B-cell CLL/lymphoma 1; B-cell leukemia 1; B-cell lymphoma 1 protein; BCL-1; BCL1; BCL1 oncogene; CCND 1; CCND1; CCND1 protein; CCND1/FSTL3 fusion gene, included; CCND1/IGHG1 fusion gene; CCND1/IGHG1 fusion gene, included; CCND1/IGLC1 fusion gene, included; CCND1/PTH fusion gene, included; Parathyroid adenomatosis 1; PRAD1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 32kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, dog
产品介绍：The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression ａnd degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with ａnd functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb ａnd the expression of this gene is regulated positively by Rb. Mutations, amplification ａnd overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors ａnd may contribute to tumorigenesis.细胞周期素D1蛋白（Cyclin D1）是细胞周期中的重要调控因子，它作用于细胞周期的G1→S期调控点，为G1期的限速步骤。 细胞周期蛋白D1-Cyclin D1的过度表达使细胞周期G1期缩短，细胞生长对有丝分裂原和粘附信号的需求降低，*终引发肿瘤的发生。该抗原的氨基酸序列抗原决定簇-结合位点，我们选在了细胞质的粗面内质网。越来越多的研究表明。CyclinD1在正常细胞周期及肿瘤的调节中起着重要作用。周期素D1/Bcl-1属于细胞周期调控蛋白家族成员，在细胞周期从G1进入S期中起到重要作用。周期素D1的过度表达与癌症的早发、肿瘤的进展和转移相关。该抗体可用于细胞周期方面的研究，产品图片Tissue/cell: human placenta tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Cyclin D1 Polyclonal Antibody, Unconjugated（bs-0623R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingTissue/cell: human endometrium carcinoma; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Cyclin D1 Polyclonal Antibody, Unconjugated（bs-0623R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining