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货号：BY-1148R
英文名称：Anti-Cyclin D2
中文名称：周期素D2抗体
其他名称：CCND 2; CCND2; CyclinD2; G1/S specific cyclin D2; KIAK0002; MGC102758.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 35kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression ａnd degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with ａnd functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb ａnd the expression of this gene is regulated positively by Rb. Mutations, amplification ａnd overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors ａnd may contribute to tumorigenesis.Subunit : Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation ａnd modulation of CDK4-mediated kinase activity.Subcellular Location : Nucleus. Cytoplasm. Membrane.Similarity : Belongs to the cyclin family. Cyclin D subfamily.Contains 1 cyclin N-terminal domain.Cyclin D2与周期素D1一样，为细胞周期中G1期进入S期的一个重要调控因子。细胞周期素是周期素依赖激酶的调节因子，不同的细胞周期素控制着细胞周期中不同的特定阶段。Cyclin D2通过激活CdK4或CdK6等，促进DNA合成，加速细胞增殖。主要用于B细胞淋巴瘤、乳腺癌、头颈部鳞癌、食道癌、肝癌和肺癌等恶性肿瘤的研究。
