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货号：BY-0282R
英文名称：Anti-Cyclin C
中文名称：周期素C抗体
其他名称：CCNC; CycC; Cyclin C; hSRB11; OTTHUMP00000016897.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 53kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Cyclin C was originally identified by a genetic screen for human ａnd Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro ａnd in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C ａnd cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.周期素 C属于高度保守的周期素家族。不同的周期素出现在不同的细胞增殖周期。能结合和激活CDK激酶。 周期素 C（Cyclin C）主要出现在G1期（间隙期（或生长期）（G1）：是在有丝分裂（M）和开始DNA合成（S）期之间的阶段；产品图片Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Cyclin C Polyclonal Antibody, Unconjugated（bs-0282R） 1:300, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining
