本公司经销Caveolin-1，细胞质膜微囊蛋白-1抗体，克隆类型为polyclonal，宿主来源是Rabbit，Caveolin-1细胞质膜微囊蛋白-1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1453R
英文名称：Anti-Caveolin-1
中文名称：细胞质膜微囊蛋白-1抗体
其他名称：opamine D3 receptor; Caveolin1; Caveolin 1; 3 dopamine receptor; D; Dopamine receptor D3; DRD; ETM1; FET1; Cav-1; ETM1; CAV 1; CAV1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：This is one of the five types （D1 to D5） of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is expressed in phylogenetically older regions of the brain, suggesting that it plays a role in cognitive ａnd emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, ａnd Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay （NMD）.Subunit : Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 ａnd syntaxin. Interacts with rotavirus A NSP4. Interacts （via the N-terminus） with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 ａnd JUP （By similarity）. Interacts with BMX ａnd BTK.Subcellular Location : Golgi apparatus membrane;Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.Tissue Specificity : Expressed in muscle ａnd lung, less so in liver, brain ａnd kidney.Similarity : Belongs to the caveolin family.信号传导（Signaling Intermediates） Caveolin-1（小凹蛋白）是细胞生长相关信号途径及肿瘤发生发展过程中重要的抑制因子，Caveolae是细胞膜内的特殊膜结构，参与包括细胞的分子运输、细胞粘附和信号转导在内的多种细胞活动。Caveolin-1是Caveolae中重要的结构蛋白，抑制细胞生长，与多种人类肿瘤发生发展相关的信号分子相互作用。Caveolin在信号转导的整合中起支架蛋白的作用。Caveolin构成了一个蛋白家族，他们是细胞质膜中发夹样结构域的主要结构成分。Caveolin在信号转导的整合中起支架蛋白的作用。至今已经鉴定了3种Caveolin （Caveolin-1、2 和3），它们具有不同的组织分布。Caveolin-1涉及乳腺上皮细胞增生的发病机制。该抗体可识别α和β型Caveolin-1。产品图片Overlay histogram showing Mouse kidney cells stained with bs-1453R-PE （red line）. The cells were fixed with 1% paraformaldehyde （10 min） ａnd then permeabilized with 1x PBS /0.2%TritonX-100 for 5 min.The cells were then incubated with the antibody （bs-1453R-PE, 2ug/1x106cells） for 30 min at 22-25°C. Isotype control antibody （black line） was rabbit IgG （2ug/1x106cells） used under the same conditions. Acquisition of events were used for analysis.