产品展示
Anti-CD158NK细胞抑制性受体2DL4抗体
点击次数：309发布时间：2012/12/26 9:21:57
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-2643R
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详细内容
货号：BY-2643R
英文名称：Anti-CD158
中文名称：NK细胞抑制性受体2DL4抗体
其他名称：Killer cell immunoglobulin-like receptor 2DL4; MHC class I NK cell receptor KIR103AS; KIR103; CD158d; CD158 antigen like family member D; CD158D; G9P; Killer cell immunoglobulin like receptor, two domains, long cytoplasmic tail, 4 ; Killer cell inhibitory receptor 103AS; KIR 103AS; KIR103AS; NK cell receptor; natural killer cell inhibitory receptor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Killer cell immunoglobulin-like receptors （KIRs） are transmembrane glycoproteins expressed by natural killer cells ａnd subsets of T cells. The KIR genes are polymorphic ａnd highly homologous ａnd they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex （LRC）. The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes （KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2）. The KIR proteins are classified by the number of extracellular immunoglobulin domains （2D or 3D） ａnd by whether they have a long （L） or short （S） cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif （ITIM）, while KIR proteins with the short cytoplasmic domain lack the ITIM motif ａnd instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
