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Anti-Caspase 4半胱胺酸蛋白酶蛋白-4抗体
点击次数：221发布时间：2012/12/26 9:26:31
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-0082R
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货号：BY-0082R
英文名称：Anti-Caspase 4
中文名称：半胱胺酸蛋白酶蛋白-4抗体
其他名称：Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP4; Caspase4; Caspase-4;ICE（rel）II; ICEREL II; ICH2; TX; ICH 2 protease; ICH2; Mih1/TX.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20/33kDa
纯化方法：affinity purified by Protein A
交叉反应：rat, mo, Rb, hu, chk, Danio rerio
产品介绍：Caspase 4 is a 377 amino acid protein （43 kDa） that belongs to the Ced3/ICE family of cystein proteases. Caspase 4 is an "upstream" caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 ａnd p10 subunits which have 67% homology to mature Caspase 1 over the equivalent coding sequences. Caspase 4 is capable of cleaving itself ａnd the p30 Caspase 1 precursor, ａnd of inducing apoptosis in transfected insect or COS cells. In high concentrations, it can also cleave the nuclear DNA enzyme PARP but the biological relevance of this cleavage is unclear. Caspase 4 mRNA is found in most tissues examined with the exception of the brain. Highest expression is found in spleen ａnd lung, with moderate expression in heart ａnd liver. Low expression is observed with skeletal muscle, kidney, ａnd testis.Function : Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.Subunit : Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small ａnd a large subunit.Tissue Specificity : Widely expressed, with highest levels in spleen ａnd lung. Moderate expression in heart ａnd liver, low expression in skeletal muscle, kidney ａnd testis. Not found in the brain.Post-translational modifications : The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.Similarity : Belongs to the peptidase C14A family.Contains 1 CARD domain.产品图片11112222
