本公司经销caspase-3 p12 subunit，活化半胱胺酸蛋白酶蛋白-3抗体，克隆类型为polyclonal，宿主来源是Rabbit，caspase-3 p12 subunit活化半胱胺酸蛋白酶蛋白-3抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0087R
英文名称：Anti-caspase-3 p12 subunit
中文名称：活化半胱胺酸蛋白酶蛋白-3抗体
其他名称：Caspase-3 subunit p17; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds; PARP cleavage protease; SCA 1; SCA1; SREBP cleavage activity 1; Yama.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 12; 32kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, Rb
产品介绍：The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases （e.g. Caspases 8, 9 ａnd 10）. The processed form of Caspase 3 consists of large （17kDa） ａnd small （12kDa） subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 ａnd Asp175 Ser176. The active Caspase 3 proteolytically cleaves ａnd activates other caspases （e.g. Caspases 6, 7 ａnd 9）, as well as relevant targets in the cells （e.g. PARP ａnd DFF）. Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types （e.g. commonly reported in epithelial cells of skin, renal proximal tubules ａnd collecting ducts）. Differences in the level of Caspase 3 have been reported in cells of short lived nature （eg germinal centre B cells） ａnd those that are long lived （eg mantle zone B cells）. Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer＇s disease.正常情况下caspase-3以无活性酶原形式存在于细胞浆中。当 caspase-3被上游caspases激活，生成活化的caspase-3 p17和p12亚基，对细胞凋亡的发生和调制发挥重要作用。