本公司经销CACH2/CaV1.2，L型钙通道蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，CACH2/CaV1.2L型钙通道蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2776R
英文名称：Anti-CACH2/CaV1.2
中文名称：L型钙通道蛋白抗体
其他名称：CACH 2;CACH2; CACN 2; CACN2; CACNA1C; CACNL1A1; Calcium channel cardic dihydropyridine sensitive alpha 1 subunit; Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle; Calcium channel voltage dependent L type alpha 1C subunit; CaV1.2; CCHL1A1; DHPR alpha 1 subunit; TS; Voltage dependent L type calcium channel alpha 1C subunit; Voltage dependent L type calcium channel subunit alpha 1C; Voltage gated calcium channel alpha subunit Cav1.2; Voltage gated calcium channel subunit alpha Cav1.2;
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 240kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, pig, cow, hrs, dog
产品介绍：The receptor for the 1,4-dihydropyrodine （DHPR） class of Ca2+ channel is most abundant in the transverse tubular membranes of skeletal muscle. DHRP is essential in excitation-contraction （E-C） coupling ａnd has been proposed to have a dual function as a calcium channel ａnd voltage sensor. Skeletal muscle DHRP consists of four subunits: alpha1 （170kDa）; alpha2 （175kDa non-reduced, 150kDa reduced）; beta （52kDa） ａnd gamma （32kDa）.Subcellular Location : Membrane. Cell membrane. The interaction between RRAD ａnd CACNB2 regulates its trafficking to the cell membrane.Tissue Specificity : Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells ａnd vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.Involvement in disease; Defects in CACNA1C are the cause of Timothy syndrome （TS） . TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers ａnd toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities ａnd autism.Defects in CACNA1C are the cause of Brugada syndrome type 3 （BRGDA3）. A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block ａnd ST segment elevation on an electrocardiogram （ECG）. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs （called ventricular fibrillation）, the individual will faint ａnd may die in a few minutes if the heart is not reset.产品图片Antigen: bs-2776P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.