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Anti-Claudin 1紧密连接蛋白1抗体(C端)
点击次数：238发布时间：2012/12/26 9:33:20
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-0790R
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货号：BY-0790R
英文名称：Anti-Claudin 1
中文名称：紧密连接蛋白1抗体（C端）
其他名称：claudin; Claudin1; CLD 1; CLD1; CLDN 1; CLDN1; ILVASC; SEMP 1; SEMP1; Senescence associated epithelial membrane protein 1; Senescence associated epithelial membrane protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 23kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, shp, dog
产品介绍：Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells ａnd serving as a physical barrier to prevent solutes ａnd water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein ａnd a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq].Function : Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.Subunit : Can form homo- ａnd heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 ａnd TJP3/ZO-3. Interacts with MPDZ ａnd INADL.Subcellular Location : Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.Tissue Specificity : Widely expressed, with highest levels in liver ａnd kidney.Similarity : Belongs to the claudin family.Claudin 1蛋白是紧密连接区相关的转膜蛋白Claudin的家族成员，在构成紧密连接的完整膜蛋白中发挥着一定作用，目前多用于肿瘤方面的研究。
