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Anti-CDC2L1细胞分裂周期蛋白2亚型1抗体
点击次数：297发布时间：2012/12/26 9:37:26
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-5746R
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详细内容
货号：BY-5746R
英文名称：Anti-CDC2L1
中文名称：细胞分裂周期蛋白2亚型1抗体
其他名称：CDC related protein kinase p58; CDC2L2; Cdk11; Cell Division Cycle 2 like 1; Cyclin Dependent Kinase 11; galactosyltransferase associated protein kinase; p58 CLK1; p58GTA Protein Kinase; PITSLRE; PITSLRE serine/threonine protein kinase CDC2L1; PITSLREA; PK58; Protein Kinase beta.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 87kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb,hrs,dog, cow, pig
产品介绍：CDC2L1 is part of the Ser/Thr protein kinase family ａnd CDC2/CDKX subfamily. CDC2L1 is involved in cell cycle progression, cytokinesis ａnd apoptosis. Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it. There are several named isoforms that arise from alternative splicing. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1, ａnd to RANBP9. The p58 isoform but not the p110 isoforms or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 ａnd SFRS7. CDC2L1 is expressed ubiquitously ａnd there is some evidence of isoform-specific tissue distribution. The p58 isoform is specifically induced in G2/M phase of the cell cycle.产品图片Antigen: bs-5746P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
