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Anti-Calsequestrin肌钙集蛋白/收钙素抗体
点击次数：327发布时间：2012/12/26 9:40:09
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-2961R
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货号：BY-2961R
英文名称：Anti-Calsequestrin
中文名称：肌钙集蛋白/收钙素抗体
其他名称：CASQ; Calsequestrin 1; Calsequestrin 1 fast twitch skeletal muscle; Calsequestrin 2; Calsequestrin 2 fast twitch cardiac muscle; Calsequestrin cardiac muscle isoform; Calsequestrin skeletal muscle isoform; Cardiac calsequestrin 2; CASQ 1; CASQ 2; PDIB1; PDIB2; Skeletal muscle calsequestrin 1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, pig, Rb
产品介绍：The sarcoplasmic reticulum （SR） is, in part, responsible for maintaining the level of intracellular calcium in cardiac ａnd skeletal muscle by storing ａnd releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation ａnd is found discretely localized to the junctional ａnd corbular （terminal cisternae） SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic ａnd has a large capacity ａnd moderate to low affinity for calcium. Function : Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein ａnd thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform （CASQ1） binds around 80 Ca（2+） ions, while the cardiac isoform （CASQ2） binds approximately 60 Ca（2+）.Subcellular Location : Sarcoplasmic reticulum lumen. Mitochondrion.Similarity : Belongs to the calsequestrin family.肌钙集蛋白，隐钙素，收钙素，是肌浆网上调控钙储存的主要结合蛋白。CASQ与内质网钙结合蛋白肌钙网蛋白具有同源性（calreticulin）。CASQ1主要在快收缩骨骼肌表达，CASQ2主要在在慢收缩骨骼肌和心肌表达。
