本公司经销Cdc14A，细胞周期调控因子14A抗体，克隆类型为polyclonal，宿主来源是Rabbit，Cdc14A细胞周期调控因子14A抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-8614R
英文名称：Anti-Cdc14A
中文名称：细胞周期调控因子14A抗体
其他名称：CDC 10;Cdc 14;Cdc 14A;Cdc 14A1;Cdc 14A2;CDC10;Cdc14;CDC14 cell division cycle 14 homolog A;CDC14 homolog A;Cdc14A1;Cdc14A2;Cell division cycle 14 homolog A;Dual specificity protein phosphatase CDC 14A;Dual specificity protein phosphatase CDC14A;hCDC14.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 67kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：In budding yeast, the Cdc14a phosphatase activates mitotic exit by dephosphorylation of specific cyclin-dependent kinase （Cdk） substrates ａnd seems to be regulated by sequestration in the nucleolus until its release during mitosis. Human Cdc14a phosphatase is highly similar to Saccharomyces cerevisiae Cdc14 ａnd is a member of the dual specificity protein Tyrosine phosphatase family. It interacts with ａnd dephosphorylates tumor suppressor protein p53 ａnd may regulate the function of p53. In addition, Cdc14a dephosphorylates hCdh1 ａnd activates APCCdh1. Cdc14a phosphatase plays a role in the regulation of the centrosome cycle, mitosis ａnd cytokinesis, thereby influencing chromosome partitioning ａnd genomic stability in human cells. Deregulated human Cdc14a phosphatase disrupts centrosome separation ａnd chromosome segregation.Function : Overproduction of hCdc14A leads to progressive cell death, accompanied by accumulation of pre-G1 DNA fragments ａnd gradual elimination of cells at the G2/M transition. In 50% of the mitotic cells, multipolar mitotic spindles ａnd misaggregated chromosomes are found. hCdc14A localizes to the centrosomes at the cell-cycle interphase stage. When the cell enters mitosis, this localization disappears suggesting that hCdc14A dissociates from the centrosomes at the G2/M transition. hCdc14A localizes to interphase centrosomes, but not to mitotic centrosomes, while hCdc14B localizes to the interphase nucleolus. Thus each isoform regulates separate cell cycle events. Cdc14A may affect cell cycle progression by its ability to dephosphorylate p53 at Ser315. This phosphatase activity is mediated by the interaction between the N-terminus of hCdc14A ａnd the C-terminus of p53.Subcellular Location : Cytoplasm.Tissue Specificity : Widely expressed.