本公司经销CDCREL/SEPT5，细胞周期调控相关蛋白1，克隆类型为polyclonal，宿主来源是Rabbit，CDCREL/SEPT5细胞周期调控相关蛋白1可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6905R
英文名称：Anti-CDCREL/SEPT5
中文名称：细胞周期调控相关蛋白1
其他名称：5 Sep;CDCrel 1;CDCREL;CDCrel-1;CDCREL1;Cell division control related protein 1;Cell division control-related protein 1;H5 antibodyHCDCREL 1;Peanut like 1;Peanut like 1 homolog;Peanut like protein 1;Peanut-like protein 1;Platelet glycoprotein Ib beta chain;PNUTL1;SEPT5;SEPT-5;SEPT 5;SEPT5_HUMAN;Septin 5;Septin5;Septin-5.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 41kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, hrs, dog
产品介绍：This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, ａnd mouse ａnd appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis ａnd results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge ａnd velocardiofacial syndromes. A translocation involving the MLL gene ａnd this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal （AACAAT） in this gene also results in read-through transcription into the downstream neighboring gene （GP1BB; platelet glycoprotein Ib）, whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010].Function : Filament-forming cytoskeletal GTPase. May play a role in cytokinesis （Potential）. May play a role in platelet secretion.Subunit : Septins polymerize into heterooligomeric protein complexes that form filaments, ａnd can associate with cellular membranes, actin filaments ａnd microtubules. GTPase activity is required for filament formation. Interacts with SEPT2 ａnd SEPT5. In platelets, associated with a complex containing STX4. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination ａnd degradation.Subcellular Location : Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granulesTissue Specificity : Expressed at high levels in the CNS, as well s in heart ａnd platelets （at protein level）.Post-translational modifications : In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate ａnd collagen.Similarity : Belongs to the septin family.SEPTIN（SEPT）家族是细胞骨架蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与细胞的分裂、细胞膜的运输以及构成细胞骨架。SEPTIN5又称细胞骨架蛋白SEPT5。