本公司经销TAPA1/CD81，CD81抗体，克隆类型为polyclonal，宿主来源是Rabbit，TAPA1/CD81CD81抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6934R
英文名称：Anti-TAPA1/CD81
中文名称：CD81抗体
其他名称：26 kDa cell surface protein TAPA 1; 26 kDa cell surface protein TAPA-1; 26 kDa cell surface protein TAPA1; CD 81; CD81; CD81 antigen; CD81 molecule; CD81_HUMAN; CVID6; S5.7; TAPA 1; Target of the antiproliferative antibody 1; Tetraspanin 28; Tetraspanin-28; Tetraspanin28; Tspan 28; Tspan-28; Tspan28.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 26kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, cow, shp, pig, dog, hrs
产品介绍：The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth ａnd motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion ａnd support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region ａnd thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008].Subunit : Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. Interacts with CD53 ａnd SCIMP.Subcellular Location : Membrane.Tissue Specificity : Hematolymphoid, neuroectodermal ａnd mesenchymal tumor cell lines.Similarity : Belongs to the tetraspanin （TM4SF） family.Involvement in disease: Defects in CD81 are the cause of immunodeficiency common variable type 6 （CVID6）; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections ａnd an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation ａnd impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.