本公司经销CADPS2，钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，CADPS2钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11500R
英文名称：Anti-CADPS2
中文名称：钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体
其他名称：Cadps2;Calcium-dependent activator protein for secretion 2;Calcium-dependent secretion activator 2;CAPS2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 147kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Calcium-dependent secretion activators （CAPS-1 ａnd CAPS-2） are calcium-binding proteins that direct neurotransmitter ａnd neuropeptide-filled vesicles to the cell membrane for secretory granule exocytosis. Both CAPS-1 ａnd CAPS-2 are expressed primarily in the brain where they regulate the secretion of various substances. The CAPS proteins contain a PH domain that is essential for regulation of exocytosis, as well as regulation of phospholipid binding. Through their regulation of neurotrophin release from granule cells, CAPS proteins help to regulate cell fate during neuronal development. CAPS-1 is thought to regulate catecholamine release from neuronal cells, while CAPS-2 is thought to regulate release of both brain-derived neurotrophic factor ａnd neurotrophin-3 from granule cells. Defects in the genes encoding CAPS-1 ａnd CAPS-2 are implicated in impaired cerebral development ａnd autism.Function : RelevanceCADPS2 （Ca2+-dependent activator protein for secretion） belongs to the CAPS/Cadps family ａnd consists of two members, CAPS1 ａnd CAPS2. Both members play an important role in secretory granule exocytosis. CADPS2 is involved in the release of two neurotrophins, brain-derived neurotrophic factor ａnd neurotrophin-3, from parallel fibers of cerebellar granule cells. CAPS proteins are expressed predominantly in the brain. CADPS2 has been found in various brain regions including the olfactory bulb, cerebrum, hippocampal formation, thalamus, mesencephalic tegmentum, cerebellum, medulla ａnd spinal cord. CADPS2 colocalizes with proteins related to exocytosis （VAMP ａnd SNAP-25） ａnd endocytosis （Dynamin I） in the cell soma ａnd processes of the mesencephalic tegmentum ａnd cerebellum.Subcellular Location : Cytoplasmic. Membrane-associated to vesicles.