产品展示
Anti-CBLN3/Cerebellin 3小脑肽3抗体
点击次数：222发布时间：2012/12/26 9:50:49
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-11537R
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货号：BY-11537R
英文名称：Anti-CBLN3/Cerebellin 3
中文名称：小脑肽3抗体
其他名称：Cbln3;Cbln 3;Cbln-3;CBLN3_HUMAN;Cerebellin-3;Cerebellin3;PRO1486.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Cerebellin （CER）, which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 （Cbln2）, Cerebellin 3 （Cbln3） ａnd Cerebellin 4 （Cbln4）, comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development ａnd synaptic plasticity in various brain regions. Cerebellin ａnd its metabolite, des-Ser（1）Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 ａnd 3 assemble into homomeric ａnd heteromeric complexes, thereby influencing each other’s degradation ａnd secretion. Cerebellin 3 is not able to form homomeric complexes, ａnd can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy （OPCA） ａnd Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.Function : May be involved in synaptic functions in the CNS.Subcellular Location : Secreted. Cell junctionSimilarity : Contains 1 C1q domain."
