本公司经销CDKL5，周期素依赖性激酶样5抗体，克隆类型为polyclonal，宿主来源是Rabbit，CDKL5周期素依赖性激酶样5抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11538R
英文名称：Anti-CDKL5
中文名称：周期素依赖性激酶样5抗体
其他名称：Cdkl5;CDKL5_HUMAN;Cyclin dependent kinase 5 transcript;Cyclin-dependent kinase-like 5;EIEE2;ISSX;Serine/threonine kinase 9;Serine/threonine-protein kinase 9;Stk9.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 105kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Cell cycle progression is controlled in part by a family of cyclin proteins ａnd cyclin-dependent kinases （Cdks）. Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes ａnd modulating their activity. CDKL5 （cyclin-dependent kinase-like 5） is a 1030 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family. Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas ａnd testis, CDKL5 is thought to play a role in cell cycle regulation. Defects in CDKL5 are a cause of several disorders, such as X-linked infantile spasm syndrome ａnd Rett syndrome.Function : Mediates phosphorylation of MECP2.Subcellular Location : Nucleus.Tissue Specificity : Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas ａnd testis.Post-translational modifications : Autophosphorylated.DISEASE : Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures ａnd spams ａnd psychomotor impairment. Translocation t（X;6）（p22.3;q14）; translocation t（X;7）（p22.3;p15）.Defects in CDKL5 are a cause of epileptic encephalopathy early infantile type 2 （EIEE2） [MIM:300672]; also known as atypical CDKL5-related Rett syndrome. EIEE2 is a severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements.Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Contains 1 protein kinase domain.