本公司经销CHN 1/Alpha-chimerin，α1-chimaerin蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，CHN 1/Alpha-chimerinα1-chimaerin蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11539R
英文名称：Anti-CHN 1/Alpha-chimerin
中文名称：α1-chimaerin蛋白抗体
其他名称：A-chimaerin;Alpha-chimerin;ARHGAP2;CHIN_HUMAN;CHN;Chn1;N chimaerin;N chimerin;N-chimaerin;N-chimerin;NC;Rho GTPase-activating protein 2;RHOGAP2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 53kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The Rac-GAP chimaerin family member Alpha-chimaerin （also known as N-chimaerin or rho GTPase-activating protein 2） has two splice variants: Alpha1 ａnd Alpha2. The ?-chimaerin variant is a neuron-specific, diacylglycerol-binding ａnd GTPase-activating protein for ras-related protein Rac 1. This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant. By inactivating Rac 1, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development. It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG （diacylglycerol）. Overexpression of Alpha1-chimaerin results in dendritic spine retraction ａnd the loss of dendritic branches. In the presence of reduced neuronal activity, Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth ａnd dendritic branching.Function : GTPase-activating protein for p21-rac ａnd a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms.Tissue Specificity : In neurons in brain regions that are involved in learning ａnd memory processes.DISEASE : Defects in CHN1 are the cause of Duane retraction syndrome type 2 （DURS2） [MIM:604356]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI （the abducens nerve） to develop normally, resulting in restriction or absence of abduction, adduction, or both, ａnd narrowing of the palpebral fissure ａnd retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.Similarity : Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 Rho-GAP domain.Contains 1 SH2 domain.