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货号:BY-11543R
英文名称:Anti-Centaurin alpha 1
中文名称:Centaurin α1抗体
其他名称:ArfGAP with dual PH domains 1;CENTA 1;CENTA1;Centaurin alpha;GCS1L;IP4/PIP3 binding protein;p42IP4;Putative MAPK activating protein PM25.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 43kDa
纯化方法:affinity purified by Protein A
交叉反应:hu, mo, rat
产品介绍:ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.Function : The centaurin alpha 1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2 adrenoceptor internalization and negatively regulates ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.Subcellular Location : Cellular localizationCytoplasmic, Nuclear and Plasma membrane