本公司经销Ctip1/BCL-11A，B淋巴细胞白血病/淋巴瘤11/锌指蛋白856抗体，克隆类型为polyclonal，宿主来源是Rabbit，Ctip1/BCL-11AB淋巴细胞白血病/淋巴瘤11/锌指蛋白856抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11544R
英文名称：Anti-Ctip1/BCL-11A
中文名称：B淋巴细胞白血病/淋巴瘤11/锌指蛋白856抗体
其他名称：B cell CLL/lymphoma 11A （zinc finger protein）;B cell CLL/lymphoma 11A （zinc finger protein） isoform 2;B cell CLL/lymphoma 11A;B cell lymphoma/leukaemia 11A;B-cell CLL/lymphoma 11A;B-cell lymphoma/leukemia 11A;BC11A_HUMAN;BCL 11A;BCL-11A;BCL11A;BCL11A B cell CLL/lymphoma 11A （zinc finger protein） isoform 1;BCL11A L;BCL11A S;BCL11A XL;BCL11AL;BCL11AS;BCL11AXL;C2H2 type zinc finger protein;COUP TF interacting protein 1;COUP-TF-interacting protein 1;Ctip 1;CTIP1;Ecotropic viral integration site 9;Ecotropic viral integration site 9 homolog;Ecotropic viral integration site 9 protein;Ecotropic viral integration site 9 protein homolog;Evi 9;EVI-9;Evi9;FLJ10173;FLJ34997;HBFQTL5;KIAA1809;Zinc finger protein 856;ZNF856.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 91kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo
产品介绍：Bcl-11a genes play crucial roles in lymphopoiesis ａnd influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, ａnd the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 ａnd MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development ａnd normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, ａnd may function as a leukemia disease gene, in part, through its interaction with Bcl-6.Function : Functions as a myeloid ａnd B-cell proto-oncogene. May play important roles in leukemogenesis ａnd hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1.Subcellular Location : Cytoplasm. Nucleus. Associates with the nuclear body. Colocalizes with SUMO1 ａnd SENP2 in nuclear speckles.Tissue Specificity : Expressed at high levels in brain, spleen thymus, bone marrow ａnd testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes ａnd megakaryocytes. Expression is tightly regulated during B-cell development.Post-translational modifications : Sumoylated by SUMO1.DISEASE : Note=Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t（2;14）（p13;q32.3） causes BCL11A deregulation ａnd amplification.Similarity : Contains 6 C2H2-type zinc fingers.