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Anti-CDC123/C10orf7细胞分裂周期蛋白CDC123抗体
点击次数：280发布时间：2012/12/26 9:58:06
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-7781R
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详细内容
货号：BY-7781R
英文名称：Anti-CDC123/C10orf7
中文名称：细胞分裂周期蛋白CDC123抗体
其他名称：C10orf7;CD123_HUMAN;CDC123;Cell division cycle protein 123 homolog;D123;HT 1080;HT-1080;Protein D123;PZ32.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 39kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Required for S phase entry of the cell cycle.The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases （Cdks） ａnd cell division control （Cdc） proteins. Cdc123 （Cell division cycle protein 123）, also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine ａnd leukocytes, Cdc123 functions to destabilize Chfr （checkpoint with forkhead ａnd ring finger domain） proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.Subcellular Location : Cytoplasm.Tissue Specificity : Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon ａnd leukocytes with the highest expression in testis.
