本公司经销CDK5，周期素依赖性激酶5抗体，克隆类型为polyclonal，宿主来源是Rabbit，CDK5周期素依赖性激酶5抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0559R
英文名称：Anti-CDK5
中文名称：周期素依赖性激酶5抗体
其他名称：Cdk 5; Cell division protein kinase 5; Crk6; Cyclin dependent kinase 5; Protein kinase CDK5 splicing; PSSALRE; Serine threonine protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 32kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, cow, pig
产品介绍：CDK5 （Cyclin Dependent Kinase 5） is serine/threonine kinase involved in synaptic regulation ａnd neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression.CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, ａnd ovary. Its activity is detected almost exclusively in brain extracts. Neuronal ａnd muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 ａnd D3 type G1 cyclins ａnd can phosphorylate histone H1, TAU, MAP2 ａnd NF-H ａnd NF-M. Cdk5 activity is involved in terminal differentiation of neurons ａnd muscle cells.Function : Probably involved in the control of the cell cycle. Interacts with D1 ａnd D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 ａnd NF-H ａnd NF-M. Also interacts with p35 which activates the kinase.Subcellular Location : Cytoplasm. Cell projection > lamellipodium. Cell projection > growth cone. In axonal growth cone with extension to the peripheral lamellipodia.Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Contains 1 protein kinase domain.细胞周期素依赖性激酶-5属于小丝氨酸／苏氨酸周期素依赖性激酶家族成员，虽与其他成员序列具有同源性，但功能却完全不一样，即与细胞周期关系不大，却在中枢神经系统的发育和神经元正常功能的维持中发挥重要作用，并与一些退行性疾病及药物成瘾有密切联系。 CDK-5是神经系统中重要的蛋白激酶,周期素依赖性激酶5在神经系统发育过程中,可调节轴突生长、神经元分化及迁移.*近研究表明,周期素依赖性激酶5激酶活性失调与阿尔茨海默病的发病有关.产品图片Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-CDK5 Polyclonal Antibody, Unconjugated（bs-0559R） 1:300, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining