产品展示
Anti-CREG1E1A激活基因刺激蛋白1抗体
点击次数：219发布时间：2012/12/26 10:07:15
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-9234R
优质供应
详细内容
货号：BY-9234R
英文名称：Anti-CREG1
中文名称：E1A激活基因刺激蛋白1抗体
其他名称：Cellular repressor of E1A stimulated genes 1;Cellular repressor of E1A-stimulated genes 1;CREG;CREG1;CREG1_HUMAN;Protein CREG1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 28kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The adenovirus E1A protein both activates ａnd represses gene expression to promote cellular proliferation ａnd inhibit differentiation. CREG （cellular repressor of E1A-stimulated genes） is a cellular protein that antagonizes transcriptional activation ａnd cellular transformation by E1A. CREG was initially isolated in a yeast two-hybrid screen due to its interaction with the TATA-binding protein, TBP. Binding sites for E2F, a key transcriptional reg-ulator of cell cycle progression, are required for repression of the adeno-virus E2 promoter by CREG, ａnd CREG was shown to inhibit activation by E2F. CREG is broadly expressed in adult tissues ａnd is regulated during embryonic development. CREG is a secreted glycoprotein which enhances differentiation of mouse embryonic stem cells ａnd human NTERA-2 cells. CREG activity may contribute to the transcriptional control of cell growth ａnd differentiation.Subcellular Location : Secreted.
