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Anti-CHPT1甘油二酯胆碱磷酸转移酶抗体
点击次数：244发布时间：2012/12/26 10:08:09
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-9725R
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货号：BY-9725R
英文名称：Anti-CHPT1
中文名称：甘油二酯胆碱磷酸转移酶抗体
其他名称：AAPT1-like protein;Cholinephosphotransferase 1;chpt1;CHPT1_HUMAN;Diacylglycerol cholinephosphotransferase 1;hCPT1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 45kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：CHPT1, also known as AAPT1-like protein ａnd Diacylglycerol cholinephosphotransferase 1, is a 406 amino acid multi-pass membrane protein that is localized to the golgi apparatus. By catalyzing the phosphatidylcholine biosynthesis from CDP-choline, it plays an essential role in the formation ａnd maintenance of vesicular membranes. CHPT1 is most abundant in testis, as well as small intestine, heart, colon, spleen ａnd prostate. Expression of CHPT1 is increased in cancerous breast cells as compared to normal breast cell lines ａnd it has been determined that the CHPT1 gene exhibits mutations within the cancerous cells. Interestingly, exposure to mustard gas significantly decreases CHPT1 gene expression ａnd activity, an event that may play an important role in the development of acute respiratory distress syndrome （ARDS）. There are two isoforms of CHPT1 that are produced as a result of alternative splicing events. Subcellular Location : Golgi apparatus membrane.Tissue Specificity : Highly expressed in testis, colon, small intestine, heart, prostate ａnd spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary ａnd thymus. Weakly expressed in the brain, placenta ａnd lung. Overexpressed in cancerous breast epithelial cell lines.
