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Anti-CK2细胞角蛋白2抗体
点击次数：250发布时间：2012/12/26 10:09:44
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-1005R
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详细内容
货号：BY-1005R
英文名称：Anti-CK2
中文名称：细胞角蛋白2抗体
其他名称：CK2; Cytokeratin 2; KRT2B; keratin 76; CK 2P; CK2P; Cytokeratin 2P; Cytokeratin2; Cytokeratin2P; HUMCYT 2A; HUMCYT2A; K2P; Keratin 2p; Keratin 76; Keratin type II cytoskeletal 2 ora; Keratin2p; Keratin76; KRT 2B;KRT 2P; KRT 76; KRT2B; KRT2P; KRT76.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 70kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Keratins are a group of water-insoluble proteins that form monofilaments, a class of intermediate filament. These filaments form part of the cytoskeletal complex in epidermis ａnd in most other epithelial tissues. Nineteen human epithelial keratins are resolved with two-dimensional gels electrophoresis （1）. These can be divided into acid （pI 6.0） subfamilies. The acidic keratins have molecular weights of 56.5, 55, 51, 50, 50’, 48, 46, 45 ａnd 40 kD. The basic keratins have molecular weights of 65-67, 64, 59, 58, 56 ａnd 52kD. Members of the acidic ａnd basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, ａnd disease state （2-4）. The 56.5/65-67kD pair is present in keratinized （differentiated） epidermis. The 55/64kD pair is characteristic of normal （corneal-type） epithelial differentiation （1,2）. The 51/59kD pair is characteristic of the stratified squamous epithelial of internal organism such as esophagus ａnd tongue （1,3）. The 51/58kD pair is a keratinocyte marker; this pair is present in almost all stratified epithelia irrespective of the state of cellular stratification （1,2）. The 48/56kD pair is characteristic of hyperproliferative （de-differentiated） keratinocytes （1,5）. The 45/52kD pair ａnd to a lesser extent, the 46/54kD pair are characteristic of simple epithelia （1）. The 40kD keratin is present in most epithelia except adult epidermis （1）.
