本公司经销CK4，细胞角蛋白4抗体，克隆类型为polyclonal，宿主来源是Rabbit，CK4细胞角蛋白4抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1006R
英文名称：Anti-CK4
中文名称：细胞角蛋白4抗体
其他名称：CK 4; CK4; CYK 4; CYK4; Cytokeratin4; Cytokeratin 4; Cytokeratin-4; FLJ31692; K4; Keratin 4; Keratin type II cytoskeletal 4; Keratin4; KRT 4; KRT4.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 57kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, Rb, cow, hrs, dog
产品介绍：CK4 （Keratin, type II cytoskeletal 4; CK-4; Keratin-4; K4; Cytoskeletal 57 kDa keratin） is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple ａnd stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal ａnd esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, ａnd anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.Belongs to the intermediate filament family.Function : Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth ａnd lingual mucosa, ａnd in cells ａnd cell clusters in the mucosa ａnd serous gland ducts of the esophageal submucosa （at protein level）. Expressed widely in the exocervix ａnd esophageal epithelium, with lowest levels detected in the basal cell layer.DISEASE : Defects in KRT4 are a cause of white sponge nevus of cannon （WSN） [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, ａnd spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, ａnd vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia ａnd rectum are involved.Similarity : Belongs to the intermediate filament family.结构蛋白（Structural Proteins）细胞角蛋白是一类与结构相关的蛋白家族，他们在上皮细胞中形成了细胞骨架中间丝。角蛋白在上皮细胞中往往成对存在，具有组织和细胞特异性。存在于口腔黏膜、鼻腔、食道和肛门生殖器上皮中的特异角蛋白为CK4和CK13。CK4是II型角蛋白，普遍存在于非角质化的鳞状上皮细胞中，CK4表达于基底细胞，也表达于鳞状细胞癌。