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Anti-CIDEB促进凋亡基因抗体
点击次数：299发布时间：2012/12/26 10:12:18
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-0544R
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详细内容
货号：BY-0544R
英文名称：Anti-CIDEB
中文名称：促进凋亡基因抗体
其他名称：cell death activator CIDE-B; cell death-inducing DFFA-like effector B; Cide-b.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 24kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Apoptosis is related to many diseases ａnd induced by a family of cell death receptors ａnd their ligands. Cell death signals are transduced by death domain containing adapter molecules ａnd members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as an inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A ａnd CIDE B were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD ａnd DFF40/CAD. Expression of CIDE B induces apoptosis, which is inhibited by DFF45. CIDE B is a DFF45 inhibitable effector that promotes cell death ａnd DNA fragmentation. CIDE B is expressed mainly in liver ａnd small intestine ａnd at lower levels in spleen, colon, kidney, peripheral blood lymphocytes, ａnd bone marrow.CIDE-B（DFF45）是凋亡信号通路中新近发现的促进凋亡的基因，在细胞凋亡中有重要的作用，有学者认为：CIDE-B在周围神经元损伤后,脊髓内CIDE-B即可表达增强，诱导神经元凋亡； 若阻断CIDE-B的表达，能有效抑制神经元的凋亡。cide-b在肿瘤方面研究也日趋增多，他的抑制可能与肿瘤的发生有关。产品图片Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-CIDE-B Polyclonal Antibody, Unconjugated（bs-0544R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining
