本公司经销CDK7，周期素依赖性激酶7抗体，克隆类型为polyclonal，宿主来源是Rabbit，CDK7周期素依赖性激酶7抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0569R
英文名称：Anti-CDK7
中文名称：周期素依赖性激酶7抗体
其他名称：Cyclin H; MAT1; Cyclin Dependent Kinase 7; CAK1; MO15; CDKN7; serine/threonine kinase; STK1; serine/threonine protein kinase 1; MO15 homolog,Xenopus laevis, cdk-activating kinase; Cdk-activating kinase; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; 39 KDa protein kinase; CR4 protein kinase; CRK4.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The protein encoded by this gene is a member of the cyclin-dependent protein kinase （CDK） family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, ａnd Schizosaccharomyces pombe cdc2, ａnd are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H ａnd MAT1, which functions as a Cdk-activating kinase （CAK）. It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation ａnd DNA repair. This protein is thought to serve as a direct link between the regulation of transcription ａnd the cell cycle. Function : Cyclin-dependent kinases （CDKs） are activated by the binding to a cyclin ａnd mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase （CAK） complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 ａnd CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain （CTD） of its large subunit （POLR2A）, allowing its escape from the promoter ａnd elongation of the transcripts. Involved in cell cycle control ａnd in RNA transcription by RNA polymerase II. Its expression ａnd activity are constant throughout the cell cycle.Subcellular Location : Nucleus.Tissue Specificity : Ubiquitous.Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Contains 1 protein kinase domain.