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Anti-CDKN1C/p57 Kip2周期蛋白依赖激酶抑制因子1C抗体
点击次数：300发布时间：2012/12/26 10:14:40
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-0538R
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详细内容
货号：BY-0538R
英文名称：Anti-CDKN1C/p57 Kip2
中文名称：周期蛋白依赖激酶抑制因子1C抗体
其他名称：Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip 2; p57Kip2; WBS.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 13/38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, cow, shp
产品介绍：Potent tight-binding inhibitor of several G1 cyclin/CDK complexes （cyclin E-CDK2, cyclin D2-CDK4, ａnd cyclin A-CDK2） and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [Subcellular location] Nucleus. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas ａnd testis. High levels are seen in the placenta while low levels are seen in the liver. Defects in CDKN1C are involved in tumor formation. Belongs to the CDI family.p57 Kip-2调控周期蛋白依赖蛋白激酶、G1 期, 是细胞周期蛋白依赖性激酶（CDK）的抑制蛋白。它通过调控细胞周期进程，参与肿瘤细胞的增殖、分化与凋亡。在多种肿瘤中均发现p57,kip2表达异常，在某些肿瘤中是一种独立的预后因素，与肿瘤的发生、发展及预后有着密切关系。产品图片Antigen: bs-0538P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
