本公司经销Collagen II alpha 1/Chondrocalcin，Ⅱ型胶原α1蛋白/软骨钙素抗体，克隆类型为polyclonal，宿主来源是Rabbit，Collagen II alpha 1/ChondrocalcinⅡ型胶原α1蛋白/软骨钙素抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4850R
英文名称：Anti-Collagen II alpha 1/Chondrocalcin
中文名称：Ⅱ型胶原α1蛋白/软骨钙素抗体
其他名称：Collagen II alpha 1; COL2A1; COL2A1 protein; collagen, type II, alpha 1; collagen alpha-1（II）; type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; Cartilage collagen; Chondrocalcin; COL11A3; Collagen alpha 1（II） chain precursor; Collagen II alpha 1 polypeptide; Collagen type II alpha 1 （primary osteoarthritis spondyloepiphyseal dysplasia congenital）; MGC131516; SEDC.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 27kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, cow, dog, chk, Gpig, pig
产品介绍：Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth ａnd for the ability of cartilage to resist compressive forces.The extensive family of COL gene products （collagens） is composed of several chain types, including fibril-forming interstitial collagens （types I, II, III ａnd V） ａnd basement membrane collagens （type IV）, each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength ａnd are the major components of connective tissue, such as tendons ａnd cartilage. All collagens contain a triple helix domain ａnd frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture ａnd function. In cartilage, Collagen Type II constitutes the bulk of the fibril. Sensitization with Collagen Type II induces an erosive polyarthritis in rats, mice ａnd higher primates which can resemble rheumatoid arthritis ａnd relapsing polychrondritis.Function : Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth ａnd for the ability of cartilage to resist compressive forces.Subunit : Homotrimers of alpha 1（II） chains.Subcellular Location : Secreted, extracellular space, extracellular matrix.Tissue Specificity : Isoform 2 is highly expressed in juvenile chondrocyte ａnd low in fetal chondrocyte.Post-translational modifications : Proline residues at the third position of the tripeptide repeating unit （G-X-Y） are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit （G-X-Y） are hydroxylated in some of the chains.The N-telopeptide is covalently linked to the helical COL2 region of alpha 1（IX）, alpha 2（IX） ａnd alpha 3（IX） chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3（IX） COL2.DISEASE : Defects in COL2A1 are the cause of spondyloepiphyseal dysplasia congenital type （SEDC） [MIM:183900]. This disorder is characterized by disproportionate short stature ａnd pleiotropic involvement of the skeletal ａnd ocular systems.[DISEASE] Defects in COL2A1 are the cause of spondyloepimetaphyseal dysplasia Strudwick type （SEMD-STR） [MIM:184250]. A bone disease characterized by disproportionate short stature from birth, with a very short trunk ａnd shortened limbs, ａnd skeletal abnormalities including lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, ａnd abnormal epiphyses or metaphyses. A distinctive radiographic feature is irregular sclerotic changes, described as dappled in the metaphyses of the long bones.[DISEASE] Defects in COL2A1 are the cause of achondrogenesis type 2 （ACG2） [MIM:200610]; also known as achondrogenesis-hypochondrogenesis type II. ACG2 is a disease characterized by the absence of ossification in the vertebral column, sacrum ａnd pubic bones.[DISEASE] Defects in COL2A1 are the cause of Legg-Calve-Perthes disease （LCPD） [MIM:150600]; also known as Legg-Perthes disease or Perthes disease. LCPD is characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture ａnd collapse, ａnd repair ａnd remodeling of the bone. [DISEASE] Defects in COL2A1 are the cause of Kniest dysplasia （KD） [MIM:156550]; also known as Kniest syndrome or metatropic dwarfism type II. KD is a moderately severe chondrodysplasia phenotype that results from mutations in the COL2A1 gene. Characteristics of the disorder include a short trunk ａnd extremities, mid-face hypoplasia, cleft palate, myopia, retinal detachment, ａnd hearing loss.Similarity : Belongs to the fibrillar collagen family.Contains 1 fibrillar collagen NC1 domain.Contains 1 VWFC domain.Ⅱ型胶原是软骨基质中的一种结构蛋白；Ⅱ型胶原不与Ⅰ, Ⅲ, Ⅳ, Ⅴ, Ⅵ胶原以及其它血清蛋白或非胶原性细胞外相关蛋白起交叉反应。II型胶原*先发现于软骨基质中，在眼睛中也有少量存在。组成II型胶原的纤维较I型胶原更纤细。该抗体可以特异性识别II型胶原，与其他类型的胶原无交叉反应，抗II型胶原抗体-主要用于Ⅱ型胶原分布及变态反应方面及良/恶性肿瘤的细胞外基质方面的研究。