本公司经销c-fos，c-fos抗体，克隆类型为polyclonal，宿主来源是Rabbit，c-fosc-fos抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0469R
英文名称：Anti-c-fos
中文名称：c-fos抗体
其他名称：Cellular oncogene fos; FBJ murine osteosarcoma viral v fos oncogene homolog antibody FBJ Osteosarcoma Virus; FOS; FOS protein; G0 G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; v fos FBJ murine osteosarcoma viral oncogene homolog.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, pig
产品介绍：The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, ａnd FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, ａnd transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, c-fos ａnd JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form ａnd maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation ａnd differentiation. Subunit: Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB. Belongs to the bZIP family. Fos subfamily. Subcellular Location: Nucleus.c-fos的作用主要用于各种类型的恶性肿瘤如食管癌、鼻咽癌、乳腺癌、结肠癌以及脑病的研究。 c-fos原癌基因及其蛋白产物不仅参与细胞的正常生长、分化过程，而且也参与细胞内信息传递过程和细胞的能量代谢过程，对细胞的增生、分化、转化都有调节作用、在生命活动中起着极为基础而重要的作用。产品图片Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-C-fos Polyclonal Antibody, Unconjugated（bs-0469R） 1:300, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingTissue/cell: human gastric carcinoma;4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-C-fos Polyclonal Antibody, Unconjugated（bs-0469R） 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, FITC conjugated（bs-0295G-FITC）used at 1:200 dilution for 40 minutes at 37°C.