产品展示
Anti-phospho-CRK (Ser41)磷酸化CRK抗体
点击次数：528发布时间：2012/12/26 10:25:19
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-5264R
优质供应
详细内容
货号：BY-5264R
英文名称：Anti-phospho-CRK （Ser41）
中文名称：磷酸化CRK抗体
其他名称：CRK CRK isoform 2; CRK isoform II; CRKII; p38; Proto oncogene C crk; v crk avian sarcoma virus CT10 oncogene homolog ; v crk sarcoma virus CT10 oncogene homolog; v crk sarcoma virus CT10 oncogene homolog （avian）; Adapter molecule crk; Avian sarcoma virus CT10 （v crk） oncogene homolog.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Crk p38 （CrkII） is an isoform of the protein Crk. CrkI ａnd CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI. Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 ａnd SH3 domains （src-homology domains） ａnd is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation ａnd its invasive growth.
