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白介素2受体γ链抗体，Anti-IL-2R gamma/CD132抗体
点击次数：234发布时间：2012/12/5 15:53:19
更新日期：2022/5/31 10:00:40
所 在 地：欧洲
产品型号：
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详细内容
【产品名称】：白介素2受体γ链抗体，Anti-IL-2R gamma/CD132抗体
【产品类型】：一抗
【产品编号】：BYk-2545R
【相关标记】: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
【性 状】： Lyophilized or Liquid
【浓 度】： 1mg/1ml
【亚 型】： IgG
【规 格】：0.1ml/100ug，0.2ml/200ug
【抗体来源】： Rabbit OR MOUSE
【克隆类型】： polyclonal or monoclonal
【产品用途】：科研实验，用于免疫组化实验，WB实验、IF、IP、ELISA实验，相应的标记抗体有HRP标记抗体，FITC标记，BIO等。
【贮 存】： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
【产品介绍】： Interleukin 2 （IL2） receptor gamma chain （IL5212R gamma） is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, ａnd neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, ａnd gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 （IL2R alpha）, CD122 （IL2R beta）, CD124 （IL4R alpha）, CD127 （IL7R）, ａnd others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, ａnd IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development ａnd activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins.
In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 （Janus Kinase 3）, JAK1, Syc, ａnd Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 （Signal Transducer ａnd Activator of Transcription 3）, STAT5, ａnd STAT6.
The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, ａnd IL9 exert their effects through cascades, which activate STAT3 ａnd STAT5, while IL4 activates STAT6. IL2 ａnd IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement. Mutation of IL2R gamma has been determined to be the cause of severe X-linked combined immunodeficiency （X SCID）, a disease that is characterized by the absence of T cells ａnd NK cells.
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“白介素2受体γ链抗体，Anti-IL-2R gamma/CD132抗体”应用于IHC、WB、 IF、IP、ELISA，质量保证，无效免费退换，另外本公司生产经营ELISA试剂盒，生物试剂，细胞株，培养基，各种标记二抗、免疫印迹常用试剂、免疫组化常用试剂，欢迎来电咨询！
