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核苷酸内焦磷酸酶/磷酸二酯酶1抗体,Anti-ENPP1/PC1/3抗体
点击次数：370发布时间：2012/12/18 9:57:56
更新日期：2022/5/31 10:00:52
所 在 地：中国大陆
产品型号：
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产品名称 核苷酸内焦磷酸酶/磷酸二酯酶1抗体,Anti-ENPP1/PC1/3抗体
产品编号 BYk-1760R
相关标记 HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-Cy5 PE-Cy5.5
PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
浓 度 1mg/1ml
抗体来源 Rabbit OR MOUSE
克隆类型 polyclonal or monoclonal
产品类型 一抗
产品用途 科研实验，用于免疫组化实验，WB实验、IF、IP、ELISA实验，相应的标记抗体有HRP标记抗体，FITC标记，BIO等。
性 状 Lyophilized or Liquid
亚 型 IgG
核苷酸内焦磷酸酶/磷酸二酯酶1抗体,Anti-ENPP1/PC1/3抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核苷酸内焦磷酸酶/磷酸二酯酶1抗体,Anti-ENPP1/PC1/3抗体产品说明：
ENPP1 has a broad specificity ａnd cleaves a variety of substrates, including phosphodiester bonds of nucleotides ａnd nucleotide sugars ａnd pyrophosphate bonds of nucleotides ａnd nucleotide sugars. It can hydrolyze nucleoside 5＇ triphosphates such as ATP, GTP, CTP, TTP ａnd UTP to their corresponding monophosphates with release of pyrophosphate. It can also hydrolyze diadenosine polyphosphates ａnd 3＇,5＇-cAMP to AMP. It may play a role in the regulation of pyrophosphate production, the regulation of the availability of nucleotide sugars in the endoplasmic reticulum ａnd Golgi, ａnd the regulation of purinergic signaling.
The subtilisin-like Prohormone Convertase （PC） family is a group of cellular enzymes that cleave most prohormones ａnd neuropeptide precursors. Numerous other cellular proteins, some viral proteins, ａnd bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, ａnd carboxyl-terminal domain that is heterogeneous in length ａnd sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.
