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细胞表面趋化因子受体3抗体,Anti-CXCR3/CD183抗体
点击次数：220发布时间：2012/12/19 9:05:49
更新日期：2022/5/31 10:00:52
所 在 地：中国大陆
产品型号：
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产品名称 细胞表面趋化因子受体3抗体,Anti-CXCR3/CD183抗体
产品编号 BYk-0341R
相关标记 HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-Cy5 PE-Cy5.5
PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
浓 度 1mg/1ml
抗体来源 Rabbit OR MOUSE
克隆类型 polyclonal or monoclonal
产品类型 一抗
产品用途 科研实验，用于免疫组化实验，WB实验、IF、IP、ELISA实验，相应的标记抗体有HRP标记抗体，FITC标记，BIO等。
性 状 Lyophilized or Liquid
亚 型 IgG
细胞表面趋化因子受体3抗体,Anti-CXCR3/CD183抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞表面趋化因子受体3抗体,Anti-CXCR3/CD183抗体产品说明：
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10（interferon-g-inducible 10 kDa protein）, Mig （monokine induced by interferon-g） ａnd I-TAC （interferon-inducible T cell a-chemoattractant）. IP10, Mig ａnd I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes ａnd chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization（phosphorylation-dependent receptor internalization）, cellular responses are typically rapid ａnd short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors ａnd subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, ａnd in T cells present in many types of inflamed tissues. In addition, IP10, Mig ａnd I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene ａnd its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
