产品展示
优质供应
详细内容
Product Name: IL-6, murine recombinant
Alternate Name/Synonyms: IFN-b2, B cell differentiation factor （BCDF）, BSF-2, HPGF, HSF, MGI-2, IL-6, Interleukin HP-1, B-cell hybridoma growth factor, B-cell stimulatory factor 2, CTL differentiation factor, Interferon beta-2.
Gene Symbol: IL6
Accession #: P08505
Gene ID: 16193
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Lyophilized with no additives
Molecular Weight: 21.7 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of the IL-6 dependent murine 7TD1 cells is <0.02 ng/ml, corresponding to a specific activity of >5 x 10⁷ units/mg.
Reconstitution Instructions: Reconstitute in H₂O to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers ａnd stored at 4°C for 1 week or –20°C for future use.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune ａnd inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells ａnd keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation ａnd antibody production, synergizes with IL-3 in megakaryocyte development ａnd platelet production, induces expression of hepatic acute-phase proteins, ａnd regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α ａnd gp130. Murine IL-6 is inactive on human cells, while both human ａnd murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.
